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On Maintenance of the Corpora Lutea of the Bovine With Lactogen

Departments of Dairy Husbandry, Zoology, and Genetics, University of Wisconsin

ABSTRACT

A number of investigators have reported a luteotrophic function of lactogen in the rat. (For review of earlier, related work consult Reference 4.) Moore and Nalbandov (4) present evidence to indicate that lactogen has luteotrophic activity in the ewe. However, Bradbury et al. (2) and Hisaw (3) failed to maintain corpora lutea of women or monkeys with lactogen. This study was undertaken to ascertain the effects of lactogen in maintenance of corpora lutea of intact cattle.

Animals used in this experiment were Guernsey or Holstein heifers, 15 to 22 months of age. Usually, each heifer was observed for several estrous periods, to determine the regularity of the cycle before treatment with lactogen. The lactogen preparations used in four of the trials were prepared by one of us (W. H. Mc.), according to the method of Bates (1). The amount of hormone in these preparations is expressed as gm. equivalent.