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Plasma 17-Hydroxycorticosteroid Levels in a Dairy Cow after Intravenous Administration of Hydrocortisone¹

New Jersey Agricultural Experiment Station, Sussex

ABSTRACT

First-order rate regression principles were used to characterize the rate of disappearance of hydrocortisone free alcohol from the blood plasma of a dairy cow. Four hundred mg. of hydrocortisone were infused rapidly and intravenously into a mature, lactating, Holstein cow during the sixth month of pregnancy. The disappearance of the free steroid from the blood plasma had two phases, the first a rapid disappearance with an extremely short half-life (estimated at about 0.7-minute) and the second, slower disappearance with a slope (rate constant) of 0.0769 and a biological half-life of 9.01 minutes. Presumably, the first phase represented the rapid distribution of the steroid into the body fluids and tissues, and the second phase represented the metabolism and excretion of the steroid. A volume of distribution of 58.4% of body weight was calculated for this steroid.

¹ Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers University, the State University of New Jersey, Department of Dairy Industry, New Brunswick. This work was supported in part by research grants from Swift and Company, Chicago, and Merck and Company, Rahway, New Jersey.

³ Present address: Schering Corporation, Bloomfield, New Jersey.