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The Effect of Administering 9-Alpha Fluorohydrocortisone with Sodium Sources to Ruminants^{1, 2,}

Dairy Department University of Maryland

ABSTRACT

In studies in Maryland (6, 8) it was observed that 9-alpha fluorohydrocortisone (9- F) is extremely effective for the treatment of bovine ketosis. No adverse results were observed in either normal or ketotic cows after its use except for a poor response in one case of ketosis, in which a massive dose of 300 mg. was administered. Later, however, in studies in the Los Angeles area, five deaths occurred in cows treated with 9 - F, which were attributed to hypokaliemia (8). Since these studies were in conjunction with studies on the use of various lactates, a check revealed that, in addition to 9 - F, sodium lactate had been used in these eases as well as calcium lactate and sometimes calcium gluconate.

Studies on 9 - F have shown a marked effect on sodium retention in the adrenalectomized dog (4) and rat (2). A high degree of electrolyte activity, manifested by a decrease in the urinary excretion of sodium and a rise of potassium, was demonstrated with this substance in humans (10).

¹ Paper No. A589, Contribution No. 2753 of the Maryland Agricultural Experiment Station.

² This study was supported in part by a grant from Merck & Co.; 9-alpha fluorohydrocortisone was provided by Merck & Co. and E. E. Squibb & Sons.