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The Response of Low-Fertility Cows to Chlorobutanol and Ascorbic Acid Administration^{1, 2,}

Departments of Genetics and Biochemistry, University of Wisconsin, Madison, and the Bureau of Dairy Industry, U.S.D.A.⁴

ABSTRACT

This study covers 116 cows, 53 Holsteins and 63 Guernseys, each of which had been bred four or more times previously without apparent conception.

Five g. of chlorobutanol fed daily increased the ascorbic acid concentration of the blood plasma on the day of heat and 2 days after heat and also increased the ascorbic acid concentration of the anterior pituitary, 3-day corpus luteum and endometrium as determined at the time of slaughter. The feeding of chlorobutanol with the feed made the mixture unpalatable to many of the cows and apparently induced an emphysema of the omasal wall.

Three g. of ascorbic acid injected subcutaneously every other day from the day of heat until slaughter failed to maintain an increased ascorbic acid content of the blood plasma, 3-day corpus luteum, 34-day corpus luteum, endometrium or embryo.

When the results of the studies with chlorobutanol and ascorbic acid are combined, the percentage of cows with normal embryos at 34 days after breeding is 26 in 43 control cows and 30 in 45 treated cows.

There is no evidence from these studies that ascorbic acid stimulation is significantly beneficial in increasing conception rate, in repeat-breeder cows.

¹ Paper no. 458 from the Department of Genetics, University of Wisconsin.

² This work was supported in part by a grant from Badger Breeders Coop., Shawano, Wis. Facilities, assistance and experimental animals for the major portion of the study also were furnished by that organization. Thanks are due especially to W. H. Dreher of the Badger Breeders Coop, for his willing cooperation and assistance throughout this work.

The aid given by G. V. Quicke and A. F. Weber of the Univ. of Wisconsin also is gratefully acknowledged.

³ Agent of the Bureau of Dairy Industry, U.S.D.A.

⁴ A part of this work has been done under a cooperative agreement between the Wisconsin Agr. Expt. Station and the Bureau of Dairy Industry, U.S.D.A. The funds contributed by the Bureau of Dairy Industry came as an allotment from the Research and Marketing Act.