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The Isolation and Properties of the Immune Proteins of Bovine Milk and Colostrum and their Role in Immunity: a Review

Laboratory for the Study of Hereditary and Metabolic Disorders, and the Departments of Biochemistry and Medicine, University of Utah School of Medicine, Salt Lake City

ABSTRACT

Colostrum serves a special function in order to enhance the resistance of the newborn to infectious disease. This is shown by the extremely high concentrations of immune lactoglobulins in the colostrum. These globulins are passively transferred to the offspring, where they may persist in the blood stream for many months. The lactoglobulins which have molecular weights near 180,000 pass from the intestinal tract of the calf to its blood stream. The immune lactoglobulins of bovine milk and colostrum, and the - and T-globulins of bovine serum, have been isolated and compared with respect to their physical and chemical properties.

¹ The experimental work included in this paper was performed while the author was at the Biological Laboratories of E. E. Squibb and Sons.

² This laboratory is aided by a grant from the United States Public Health Service.