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Sulfamethazine Blood and Milk Concentrations in Dairy Cows

Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

ABSTRACT

1. Sulfamethazine was administered to cows parenterally, orally, and by infusion, and blood and milk determinations were made at frequent intervals after administration.
   
2. Sulfamethazine diffuses freely from blood to milk and from udder to blood.
   
3. Concentrations of 5 mg. or more of the drug per 100 cc. of milk throughout the day depend upon a persistently high concentration (more than 10 mg. per 100 cc.) of the drug in the blood.
   
4. All three methods of administration resulted in the attainment of blood and milk concentrations considered to be bacteriostatically effective.
   
5. No evidences of systemic toxicity of the drug were noted.
   
6. In this experiment, it has been shown that levels above 5 mg. per 100 cc. of milk can be achieved after oral or parenteral administration of the drug given once a day.
   

¹ The authors are indebted to Mr. S. C. Griffith, of the Animal Industry Section, for aid in the conduct of the program, and to Mr. S. Senn and Mr. D. W. Gorton, of the Analytical Section, Lederle Laboratories Division, American Cyanamid Company, for sulfonamide analyses.

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