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The Effect of a Massive Dose at Birth of Vitamins A and D upon Blood Plasma Levels and Liver Storage in Holstein Calves¹

Department of Animal Husbandry, Cornell University, Ithaca, New York

ABSTRACT

The effect of a massive dose of vitamins A and D fed to Holstein calves at birth has been studied. The following results were obtained:

1. A significant depression in the levels of carotene in the blood plasma occurred in those calves which received the vitamin supplement as compared to those in the control group. This depression was apparent 2 weeks after the administration of the massive dose of vitamins and continued until the end of the experimental period at 6 weeks of age. The levels of both vitamin A and vitamin D in the blood plasma of the vitamin-supplemented calves were significantly higher than those levels for the control calves.
   
2. The storage of vitamins A and D in the livers of the vitamin-supplemented calves was ten times higher than that found in the control calves. No appreciable differences in liver carotene storage were observed.
   

¹ This paper is part of a thesis presented by H. D. Eaton to the Graduate School of Cornell University in partial fulfillment of the requirements for the degree of Doctor of Philosophy.