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Toxicity of Phenothiazine Derivatives Excreted in the Milk of Dairy Cows Treated with Massive Doses of the Drug^*

Dairy Department, South Carolina Agricultural Experiment Station, Clemson College, Clemson, S. C.

ABSTRACT

1. Oral administration of 125 grams of commercial phenothiazine, over twice the maximum recommended therapeutic dose, to healthy adult lactating cows produced no detectable deleterious effects other than a temporary repression of milk production.
   
2. Derivatives of phenothiazine were detected in the milk for periods of 36 to 60 hours following administration of the drug.
   
3. Young rats restricted to diets of the milk collected at the 12-hour and the 24-hour periods after dosage manifested no discernible symptoms of toxicity.
   

^* Technical publication No. 138. Presented with the approval of the Director of the South Carolina Agricultural Experiment Station.

¹ Now Department of Dairy Husbandry, Kansas State College.

² Presented data in a thesis as partial requirement for the degree of Bachelor of Science in Dairying, 1943.

³ Associate Animal Pathologist, South Carolina Agricultural Experiment Station.