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Some Observations on the Effect of Sulfa Drugs on Blood Plasma Ascorbic Acid Levels in Calves^*

From the Departments of Dairy Husbandry and Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin

ABSTRACT

The results of these experiments indicate that succinyl sulfathiazole, when fed at the low level of 2.0 grams per day to the newborn calf, was responsible for higher blood plasma ascorbic acid levels during the first week of life than those in untreated calves. No effect was noted when this drug was given at levels of 2, 10, or 15 grams daily for seven days to 8–9-month-old heifers.

Sulfapyridine, at 10- or 15-gram daily dose, did not appear to effect an increase in blood plasma ascorbic acid above normal. However, administration of the drug at the rate of 10 grams daily for seven days apparently increased subnormal levels up to, but not above, normal levels.

Sulfathiazole, when fed at the rate of 15 grams daily, definitely stimulated an increase in blood plasma ascorbic acid similar to that of chlorobutanol, but different in that it required a longer period to reach peak levels.

Chlorobutanol, fed at the rate of 3 grams daily for seven days, increased blood plasma ascorbic acid levels. This chlorobutanol-ascorbic acid response was not interfered with by the previous use of succinyl sulfathiazole; but a marked reduction in ascorbic acid concentration occurred when the chlorobutanol feeding period was preceded by the feeding of sulfathiazole, even though there was an interval of six days between these two feeding periods.

^* Published with the approval of the Director of the Wisconsin Agricultural Experiment Station.