HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lundquist, N. S. Articles by Phillips, P. H. Search for Related Content PubMed Articles by Lundquist, N. S. Articles by Phillips, P. H.

The Effect of Chlorobutanol on Certain Members of the B Complex in the Rumen and Blood Plasma Ascorbic Acid Levels^*

Departments of Dairy Husbandry and Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin

ABSTRACT

Conclusions: The results of this experiment indicate that chlorobutanol, when fed to a 966-pound heifer at the rate of 5 grams per day, had no detrimental effect on the rumen synthesis of thiamine, riboflavin, niacin and pantothenic acid.

The work of previous workers (1, 2, 7) was confirmed in that chlorobutanol will increase blood plasma ascorbic acid. The administration of chlorobutanol at the rate of 5 grams daily was without obvious harmful effects for a period up to 160 days. During this interval the drug sustained increased concentrations of blood plasma ascorbic acid. This dropped sharply and below normal upon removal of the drug. It required approximately one month for the heifer to regain normal concentrations of this vitamin in its blood plasma. A subsequent three-week period of chlorobutanol administration and withdrawal brought about an increase in blood plasma ascorbic acid without the sub-normal drop accompanying the withdrawal of the drug.

^* Published with the approval of the Director of the Wisconsin Agricultural Experiment Station.