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Journal of Dairy Science Vol. 27 No. 11 957-964
© 1944 by American Dairy Science Association ®
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The Stimulation and Inhibition of Milk Secretion in Goats with Diethylstilbestrol1,2

John P. Mixner3, Joseph Meites4 and C. W. Turner

From the Department of Dairy Husbandry, University of Missouri, Columbia, Missouri

ABSTRACT

The relation between lactation-stimulating and lactation-inhibiting dosages of diethylstilbestrol in dairy goats was established in these experiments. A daily dose of 0.25 mg. of diethylstilbestrol constitutes a lactation-stimulating dosage in nonparous goats while dosages varying from 1 to 4 mg. per day were progressively lactation-inhibiting in lactating goats.

As judged by the lactation-inhibiting effect, diethylstilbestrol orally administered is only about 1 per cent as effective as when administered subcutaneously.

The lactation-stimulating effects of small dosages of diethylstilbestrol are due to its ability to stimulate the secretion of the lactogenic hormone by the anterior pituitary gland while the lactation-inhibiting effects are believed to be correlated with increased adrenal-cortical activity resulting in an increased rate of deaminization of the nitrogenous precursors of milk protein. It is suggested that the hormones of the adrenal cortex play a role in regulating the course of the rising segment of the lactation curve.

FOOTNOTES

1 Contribution from the Department of Dairy Husbandry, Missouri Agricultural Experiment Station, Journal Series No. 946.

2 This study has been aided in part by a grant from the International Cancer Research Foundation.

3 Now in the Zoology Department, Louisiana State University, Baton Rouge, Louisiana.

4 Now Lieutenant U.S.A. Sanitary Corps.






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