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The Effect of Stilbestrol and Anterior Pituitary Extract upon Lactation in Goats^*

Department of Dairy Husbandry, University of Missouri

ABSTRACT

Administration of diethylstilbestrol by subcutaneous injection, orally, by inunction or diethylstilbestrol dipropionate by implantation of pellets caused copious and prolonged lactation in virgin and dry goats. This is significant because of the ability of estrogens to increase the anterior pituitary lactogenic output. One-quarter milligram per day was sufficient by injection. Oral administration appeared to be least effective up to 5 mg. per day or 20 times the subcutaneous dose. Inunction of the udder required 4 mg. daily or 16 times the subcutaneous dose. Anterior pituitary extract was effective in augmenting the production caused by diethylstilbestrol by supplementing the increased lactogen output with other anterior pituitary factors or in initiating lactation in diethylstilbestrol-treated goats. Stopping daily treatment was sometimes effective in improving production for a time but restarting treatment had little effect. Hormone treatment of normal parturient goats was not beneficial on volume of production. Treatment during the last half of pregnancy had no deleterious effect in two cases. Ovaries were essentially normal after long periods of treatment with one exception. Two goats were bred out of season after termination of diethylstilbestrol injections. One conceived and bore a kid. No adverse effect on growth or health of the goats from diethylstilbestrol treatment was observed.

^* A contribution from the Department of Dairy Husbandry, Missouri Agricultural Experiment Station, Journal series No. 824. This study was aided in part by a grant of the International Cancer Research Foundation.