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The Preparation, Properties, and Use of Gonad-Stimulating Hormones^1,

Dept. of Genetics, University of Wisconsin, Madison, Wisconsin

ABSTRACT

The phenomenal results obtained from the use of gonad-stimulating hormones in the experimental laboratory have attracted widespread attention. It is a striking thing that a baby female rat can be made to ovulate 75 or 100 eggs when the best her mother ever did was to produce 10 or 12 eggs at one time. No other agent has been known which exerts such a clear and definite effect in speeding up the process of reproduction. People's minds have been challenged with the tremendous possibilities of modifying and controlling the process of reproduction in higher animals by means of these substances. Human medicine has been interested because of ever-present clinical problems which arise from aberrant sexual function. Animal husbandmen have seen in the discovery a possibility of dealing more effectively with the problems of sterility and lowered fertility in their livestock.

After the first report of the discovery, which was only about 10 years ago, work with the gonad-stimulating hormones has settled down chiefly to investigation of their sources, chemistry, and physiological action.

¹ Paper from the Department of Genetics, Agricultural Experiment Station, University of Wisconsin. No. 215.

Published with the approval of the Director of the Station. This work was supported in part by a grant from the Alumni Research Foundation.

Presented at the annual meeting of the American Dairy Science Association, June 21–25, 1937.