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The Decrease in the Lactose Content of Milk Following the Production of Artificial Hypoglucemia^*

¹ From the Division of Agricultural Biochemistry, University of Minnesota.
² From the Division of Dairy Husbandry, University of Minnesota.

ABSTRACT

1. Hypoglucemia produced by insulin results in a marked decrease in the lactose content of the secreted milk of cows.
   
2. No paresis or coma was noted in any of the animals, although the blood sugar was reduced in one case to .01 per cent.
   
3. In two of the three experiments, a marked similarity was obtained in the trend of the blood sugar and milk sugar curves.
   
4. An increase in blood sugar following an insulin injection was found to occur when the blood was markedly depleted of sugar.
   
5. A rise in lactose at about the normal evening milking period was not forecast by an increase in the blood sugar.
   
6. It was suggested that the rise in lactose just noted was due to an outflow of stored milk secreted before the onset of the experimental hypoglucemia.
   

^* The data in this paper are taken mainly from a thesis presented by W. R. Brown in partial fulfillment for the Ph.D. degree and published with the approval of the Director as Paper No. 1381.