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The Physiological Effect of Pituitary Extract (Posterior Lobe) on the Lactating Mammary Gland^*

Department of Dairy Husbandry, University of Missouri, Columbia, Missouri

ABSTRACT

1. The maximum physiological effect indicated by a discharge of "residual" milk was obtained by approximately one-half cubic centimeter of pituitrin per 100 pounds live weight of the cow.
   
2. A temporary inhibition of milk secretion which varied in intensity with the amount of pituitrin injected was indicated by the yield of milk obtained at the next regular milking.
   
3. The inhibitory effect of 10 cc. of pituitrin lasted approximately ten hours.
   
4. The time required for the pituitrin to become effective varied with the size of the injection. The greatest yield of milk was obtained at the end of ten minutes when 12 cc. were injected whereas twenty minutes were required when only 6 cc. were used.
   
5. The data confirm the work of previous investigators in indicating that probably fat alone of the constituents of milk is influenced by this extract.
   

^* The data presented in this paper were taken from a thesis submitted by the junior author in partial fulfillment of the requirements for the degree of Master of Arts in the Graduate School of the University of Missouri, 1928.